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Clinical significance of microcirculation test machine in systemic lupus erythematosus
Clinical significance of microcirculation test machine in systemic lupus erythematosus: correlation with endothelial cell activation markers and disease activity
Objective: To evaluate whether microcirculation test machine (NC) changes are associated with the main serum endothelial cell activation markers and the disease activity of systemic lupus erythematosus (SLE).
Methods: Serum levels of vascular endothelial growth factor (VEGF), endothelin‐1 (ET‐1), soluble E‐selectin (sE‐selectin), and soluble thrombomodulin (sTM) were determined by an enzyme‐linked immunosorbent assay (ELISA) in 80 SLE patients and 33 healthy controls.
Results: Nailfold capillary abnormalities were seen in 74 out of 80 (92.5%) SLE patients. A normal capillaroscopic pattern or mild changes were found in 33 (41.25%) and moderate/severe abnormalities in 47 (58.75%) of all SLE patients. In SLE patients a capillaroscopic score >1 was more frequently associated with the presence of internal organ involvement (p<0.001) as well as with immunosuppressive therapy (p<0.01). Significant differences were found in VEGF (p<0.001), ET‐1 (p<0.001), sE‐selectin (p<0.01), and sTM (p<0.001) serum concentrations between SLE patients with a capillaroscopic score >1 and controls. SLE patients with severe/moderate capillaroscopic abnormalities showed significantly higher VEGF serum levels than patients with mild changes (p<0.001). Moreover, there was a significant positive correlation between the severity of capillaroscopic changes and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) (p<0.005) as well as between capillaroscopic score and VEGF serum levels (p<0.001).
Conclusions: Our findings confirm the usefulness of NC as a non‐invasive technique for the evaluation of microvascular involvement in SLE patients. A relationship between changes in NC, endothelial cell activation markers and clinical features of SLE suggest an important role for microvascular abnormalities in clinical manifestation of the disease.
microcirculation test machine – questions and answers
microcirculation test machine – questions and answers
microcirculation test machine is an essential imaging technique used in the study of microcirculation and one of the best diagnostic tools for the early detection of systemic sclerosis and related conditions. However, despite the increasing interest in capillary microscopy, there is still a surprising discrepancy between its potential application and its still limited use in rheumatological practice. This contrast is really surprising because few diagnostic techniques can combine all the positive features typical of capillaroscopy (low cost, uninvasiveness, repeatability, high sensitivity, good specificity, easy interpretation of results). The lack of guidelines and recommendations concerning the right way to carry out a correct capillaroscopic examination and the interpretation of the most relevant capillaroscopic abnormalities may represent one of the major drawbacks for its widespread use. Discussion about controversies on this topic should be encouraged, leading to a progressive development of capillaroscopy as a routine investigation in rheumatology.
What is microcirculation test machine?
What is microcirculation test machine?
Circulatory system is also named cardiovascular system; this includes heart, arteries, veins, capillaries, blood cells and plasma. Thus, damage on any part of cardiovascular system would cause harmful consequences, such as dizziness, migraine, breathing difficulties, tiredness and body weakness. Severe consequences would be stroke, hypertension, heart attack, myocardial infarction and etc. Therefore, prevention is the only effective way to avoid these problems and the importance of prevention should be prioritized.
Heart is an organ which plays a critical role in blood circulation. Arteries and veins are responsible for transporting blood to the entire body and transporting back to the heart. Capillaries are permeable tiny blood vessels between small arteries and veins, which are sites for nutrients and gas exchange. Therefore, if there is blockage of blood vessels, nutrients and gas cannot be transported to the entire body and back to the heart. This will accelerate the occurrence of atherosclerosis and cardiovascular diseases.
What is microcirculation test machine Advantage?
What is microcirculation test machine Advantage?
1, In 5 seconds can be observed in the microvascular circulation, simple operation and fast
2, The microscopic image is stable, clear, do not shake
3, 400 times the microcirculation of a dedicated high-resolution lens of the microscope
4, Handheld ultra-lightweight design, so that the observation of more mobility
5, With micro-focus wheel, free to adjust the focus length, the use of more convenience
6, Lens built-in LED cold light source, accurate projection illumination on an object
7, Using non-invasive way, to observe the microcirculation of human body in time
8, Observing the microcirculation for any part of human body
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